Calcium Levofolinate EP Impurity F(Calcium salt) CAS 28459-40-7(free base)
| CAS No. | 28459-40-7(free base) |
| Molecular Formula | C20H19N7O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Calcium Levofolinate EP Impurity F(Calcium salt).
As a process- or degradation-related impurity, Calcium Levofolinate EP Impurity F(Calcium salt) (CAS 28459-40-7(free base), C20H19N7O7Ca) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Calcium Levofolinate EP Impurity F(Calcium salt) (C20H19N7O7Ca) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Calcium Levofolinate EP Impurity F(Calcium salt) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19N7O7 Ca |
| Molecular Weight | 509.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Calcium Standards
- Calcium Levofolinate EP Impurity I Calcium salt (CAS 1148151-21-6)
- Calcium Levofolinate Pentahydrate - Impurity G (Dihydrate Salt) (CAS 207226-40-2)
- Calcium Levofolinate EP Impurity I (CAS 31690-11-6)
- Levofolinate Impurity 8 (CAS 4299-32-5)
- Calcium Levofolinate EP Impurity H (CAS 73951-54-9)
- Levofolinate EP Impurity H Calcium salt (CAS 73951-54-9（Free base）)
- Calcium levofolinate (CAS 80433-71-2)
- Calcium Levofolinate EP Impurity E Calcium salt (CAS 944737-05-7（free base）)
Recommended Standards
- Bendamustine Dihydroxy Impurity (CAS 109882-29-3)
- Ticagrelor Impurity 64 (CAS 2435586-40-4)
- Crizotinib Impurity 53 (CAS CATO-C4X-102553)
- 7-Oxododecanoic acid (CAS 54527-26-3)
- 2-Chloro-3-cyano-6-cyclopropyl-4-(trifluoromethyl)pyridine 2-chloro-6-cyclopropyl-4-(trifluoromethyl)pyridine-3-carbonitrile 478049-48-8 (CAS 478049-48-8)
- 2-Methyl-3-oxoisoindoline-4-carbonitrile (CAS 1217709-41-5)
- 5-Methylisobenzofuran-1,3-dione (CAS 19438-61-0)
- (S)-(-)-t-Butylsulfinamide (s)-(-)-2-methyl-2-propanesulfinamide (s)-(-)-t-butylmethylsulfinamide (s)-(-)-tert-butanesulfinamide (s)-(-)-2-methyl-propane-2-sulfinic acid amide (s)-tert-butanesulfinamide (s)-2-methyl-2-propanesulfinamide s-(-)-2-methyl-2-propanesulfinamide (s)-(-)-2-methyl-2-propanesulphinamide (s)-(-)-tert-butyl sulphinamide s-tert-butylsulfinamide (s)-2-methylpropane-2-sulfinamide (s)-(-)-tert-butylsulfinamide (s)-(-)-t-butyl sulfinamide 343338-28-3 (CAS 343338-28-3)
- 5-Chloro-1-(3-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 1152576-85-6)
- Tirzepatide Impurity 14 (CAS CATO-C4X-324014)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com